Chem prof co-publishes new study on anti-inflammatories

Date Posted: September 15, 2023 at 02:55 PM

Dr. Paolo Robert Bueno, a faculty member of the University’s Chemistry Department co-published a study focusing on anti-inflammatory properties in the Plants Journal of the Multidisciplinary Digital Publishing Institute (MDPI). 

Bueno co-authored the newly published article titled "Antioxidant, Anti-Inflammatory and Antiproliferative Effects of Osmanthus fragrans (Thunb.) Lour. Flower Extracts" with his fellow scholars, namely Steven Kuan-Hua Huang, Mon- Juan Lee and Po-Wei Tsai of the Department of Medical Science Industries, College of Health Sciences, Chang Jung Christian University, Taiwan, and Patrick Jay Garcia  Kathlia de Castro-Cruz and Roda Leron of Mapua University’s School of Chemical, Biological, and Materials Engineering and Sciences. 

According to the study, it “evaluated the antioxidant, anti-inflammatory and cytotoxic effects of OF-F extracts on prostate cancer cells (DU-145) and determined possible protein-ligand interactions of its compounds in silico.” 

Meanwhile, looking at its results, “[n]etwork analysis revealed O. fragrans (Thunb.) Lour. metabolites could affect thirteen molecular functions and thirteen biological processes in four cellular components. These metabolites inhibited key proteins of DU-145 prostate cancer using molecular docking with rutin owning the highest binding affinity with PIKR31 and AR. Hence, this study offered a new rationale for O. fragrans (Thunb.) Lour. metabolites as a medicinal herb for anticancer drug development.” 

The study can be read and downloaded via